UNCERTAINTY OF RBE MODEL IN PROTON RADIOTHERAPY BASED ON α/β RATIO AND LINEAR ENERGY TRANSFER
Loading...
Date
2019-12-05
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
License Type
Creative commons license
Abstract
Zbiór zawiera dane z eksperymentów in-vitro prowadzonych na 11 liniach komórkowych:
V79-379A, V79-753B, DLD1, SQ20B, CI-1, C3H10T1/2, SCC25, HCT116, H184B5 F5-1M/10 and HF19. Dane te zaczerpnięto z krzywych przeżywalności dostępnych w artykułach źródłowych, a następnie dopasowano do nich model liniowo-kwadratowy, z którego uzyskano parametry α i β (04_Distributions, ryc. 1). Wszystkie operacje na danych eksperymentalnych, ich odczyt, przygotowanie (01_PreaparingData.ipynb) i analizę (02_Fitting_LQmodel.ipynb) wykonano w notatnikach Jupyter. Eksperymentalna baza danych została oczyszczona z wartości odstających na podstawie kilku warunków (03_Outliers.ipynb).
Porównanie dawki biologicznej (05_SOBP.ipynb , ryc. 2) przeprowadzono na podstawie profilu dawki głębokiej i LET („data/sobp_10mln”) stosowanego w eksperymentach radiobiologicznych in vivo na myszach (folder „mc_simulation”).
The dataset includes data from in vitro experiments on 11 cell lines: V79-379A, V79-753B, DLD1, SQ20B, CI-1, C3H10T1/2, SCC25, HCT116, H184B5 F5-1M/10 and HF19 (folder „data”). These data were taken from the survival curves available in the source articles and then a linear-quadratic model was fitted to them , from which the α and β parameters were obtained (04_Distributions, Figure 1). All operations on the experimental data, their reading, preparation(01_PreaparingData.ipynb) and analysis (02_Fitting_LQmodel.ipynb) were performed in Jupyter Notebooks. The experimental database has been cleared of outliers based on several conditions(03_Outliers.ipynb). A comparison of biological dose (05_SOBP.ipynb , Figure 2) was set up on a depth-dose and LET profile („data/sobp_10mln”) as being used in radiobiological in vivo mouse experiments (folder „mc_simulation”).
The dataset includes data from in vitro experiments on 11 cell lines: V79-379A, V79-753B, DLD1, SQ20B, CI-1, C3H10T1/2, SCC25, HCT116, H184B5 F5-1M/10 and HF19 (folder „data”). These data were taken from the survival curves available in the source articles and then a linear-quadratic model was fitted to them , from which the α and β parameters were obtained (04_Distributions, Figure 1). All operations on the experimental data, their reading, preparation(01_PreaparingData.ipynb) and analysis (02_Fitting_LQmodel.ipynb) were performed in Jupyter Notebooks. The experimental database has been cleared of outliers based on several conditions(03_Outliers.ipynb). A comparison of biological dose (05_SOBP.ipynb , Figure 2) was set up on a depth-dose and LET profile („data/sobp_10mln”) as being used in radiobiological in vivo mouse experiments (folder „mc_simulation”).
Description
Keywords
radiobiologia, radioterapia, proton
Citation
Sponsorship:
European Commission: INSPIRE - INfraStructure in Proton International REsearch
Grantnumber:
730983
License Type
Uznanie autorstwa 4.0 Międzynarodowe