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Influence of therapeutic proton beam on glioblastoma multiforme proliferation index – A preliminary study

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dc.contributor.author Bogdali-Suślik, Anna M.
dc.contributor.author Rawojć, K.
dc.contributor.author Miszczyk, Justyna
dc.contributor.author Panek, Agnieszka
dc.contributor.author Woźniak, Monika
dc.contributor.author Szewczyk, Katarzyna
dc.contributor.author Książek, Teofila
dc.contributor.author Bik-Multanowski, Mirosław
dc.contributor.author Swakoń, Jan
dc.contributor.author Komenda, Wiktor
dc.contributor.author Mojżeszek, Natalia
dc.contributor.author Kajdrowicz, Tomasz
dc.contributor.author Kopeć, Renata
dc.contributor.author Olko, Paweł
dc.date.accessioned 2019-10-23T12:36:09Z
dc.date.available 2019-10-23T12:36:09Z
dc.date.issued 2019
dc.identifier.issn 0587-4254
dc.identifier.uri http://rifj.ifj.edu.pl/handle/item/306
dc.description.abstract The goal of the presented study was to compare the proliferation of different U118 MG and U251 MG glioblastoma cell lines irradiated with proton beam or X-rays in dose range 0.5-10.0 Gy. Cytokinesis-block micronucleus (CBMN) assay was carried out to study changes in proliferation presented as nuclear division index (NDI). Preliminary results suggest that protons and X-rays influence GBM (glioblastoma multiforme) cellular proliferation differently. Therapeutically, a decrease in NDI values with the increase in both types of radiation dose was found only for U251 MG cell line, thus can be classified as more radiosensitive than U118 MG cell line. Also for U251 MG GBM cell line, a therapeutic proton beam was more effective in inhibition of proliferation than X-rays. Genetic differences between GBM are supposed to be involved in the increased radiosensitivity, which is planned to be studied further by genes expression analysis. pl_PL.UTF-8
dc.language.iso eng pl_PL.UTF-8
dc.publisher Acta Physica Polonica B pl_PL.UTF-8
dc.rights Uznanie autorstwa 4.0 Międzynarodowe *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/ *
dc.subject protons pl_PL.UTF-8
dc.subject X-rays pl_PL.UTF-8
dc.subject glioblastoma multiforme pl_PL.UTF-8
dc.title Influence of therapeutic proton beam on glioblastoma multiforme proliferation index – A preliminary study pl_PL.UTF-8
dc.type Postprint pl_PL.UTF-8


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Uznanie autorstwa 4.0 Międzynarodowe Except where otherwise noted, this item's license is described as Uznanie autorstwa 4.0 Międzynarodowe