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Influence of therapeutic proton beam on glioblastoma multiforme proliferation index – A preliminary study

Show simple item record Bogdali-Suślik, Anna M. Rawojć, K. Miszczyk, Justyna Panek, Agnieszka Woźniak, Monika Szewczyk, Katarzyna Książek, Teofila Bik-Multanowski, Mirosław Swakoń, Jan Komenda, Wiktor Mojżeszek, Natalia Kajdrowicz, Tomasz Kopeć, Renata Olko, Paweł 2019-10-23T12:36:09Z 2019-10-23T12:36:09Z 2019
dc.identifier.issn 0587-4254
dc.description.abstract The goal of the presented study was to compare the proliferation of different U118 MG and U251 MG glioblastoma cell lines irradiated with proton beam or X-rays in dose range 0.5-10.0 Gy. Cytokinesis-block micronucleus (CBMN) assay was carried out to study changes in proliferation presented as nuclear division index (NDI). Preliminary results suggest that protons and X-rays influence GBM (glioblastoma multiforme) cellular proliferation differently. Therapeutically, a decrease in NDI values with the increase in both types of radiation dose was found only for U251 MG cell line, thus can be classified as more radiosensitive than U118 MG cell line. Also for U251 MG GBM cell line, a therapeutic proton beam was more effective in inhibition of proliferation than X-rays. Genetic differences between GBM are supposed to be involved in the increased radiosensitivity, which is planned to be studied further by genes expression analysis. pl_PL.UTF-8
dc.language.iso eng pl_PL.UTF-8
dc.publisher Acta Physica Polonica A pl_PL.UTF-8
dc.rights Uznanie autorstwa 4.0 Międzynarodowe *
dc.rights.uri *
dc.subject protons pl_PL.UTF-8
dc.subject X-rays pl_PL.UTF-8
dc.subject glioblastoma multiforme pl_PL.UTF-8
dc.title Influence of therapeutic proton beam on glioblastoma multiforme proliferation index – A preliminary study pl_PL.UTF-8
dc.type Article pl_PL.UTF-8

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Uznanie autorstwa 4.0 Międzynarodowe Except where otherwise noted, this item's license is described as Uznanie autorstwa 4.0 Międzynarodowe