Towards incorporation of RBE uncertainty in proton therapy planning systems

Abstract

Current arguments concerning the variability of RBE in treatment plans are reviewed and cases are discussed where proton therapy may require the use of treatment planning systems in which a variable RBE is implemented. Novel and recently introduced treatment modalities, such as Proton Arc Therapy, are considered. Risk management following the implementation of a variable RBE in proton therapy planning is also introduced and discussed.