Repozytorium IFJ PAN

Development of the IFJ Single Ion Hit facility for cells ir r adiation

Show simple item record Veselov, O. Polak, Wojciech Ugenskiene, R. Hajduk, Roman Lebed, Kateryna Lekki, Janusz Horwacik, Tomasz Dutkiewicz, Erazm Maranda, Stanisław Pieprzyca, Tomasz Sarnecki, C. Stachura, Zbigniew Szklarz, Zbigniew Styczeń, Jan 2018-01-12T12:12:48Z 2018-01-12T12:12:48Z 2005
dc.description.abstract In recent years a single ion hit facility (SIHF) has been constructed at the IFJ ion microprobe. The setup is used for the precise irradiations of living cells by a controlled number of ions. The facility allows investigations in various aspects of biomedical research, such as adaptive response, bystander effect, inverse dose-rate effect, low-dose hypersensitivity, etc. Those investigations have two very important requirements: (i) cells must be examined in their natural state and environment, i.e. without previously being killed, and preferentially, neither fixed nor stained, and (ii) a possibility of automatic irradiation of large number of cells with a computer recognition of their positions must be provided. This work presents some of the crucial features of the off-line and on-line optical systems, including self-developed software responsible for the automatic cell recognition. We also show several tests carried out to determine the efficiency of the whole setup and some segments. In conclusion, the results of our first irradiation measurements performed with living cells are demonstrated. pl_PL.UTF-8
dc.language.iso eng pl_PL.UTF-8
dc.publisher Institute of Nuclear Physics Polish Academy of Sciences pl_PL.UTF-8
dc.relation.ispartofseries Raport IFJ PAN;1973/AP
dc.title Development of the IFJ Single Ion Hit facility for cells ir r adiation pl_PL.UTF-8
dc.type Report pl_PL.UTF-8

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