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Browsing by Author "Kajdrowicz, Tomasz"

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    Eksploatacja stanowiska r adioterapi i protonow ej nowotworów oka w IFJ PAN w latach 2013-2015
    (Institute of Nuclear Physics Polish Academy of Sciences, 2015) Horwacik, Tomasz; Michalec, Barbara; Cygan-Bakoniak, Marzena; Cywicka-Jakiel, Teresa; Czaderna, Anna; Durlak, Edyta; Góra, Łukasz; Grzanka, Leszek; Kajdrowicz, Tomasz; Kędzierska, Dominika; Kos, Robret; Kozera, Anna; Krempa, Aleksander; Krempa, Artur; Lipeńska, Irena; Liszka, Małgorzata; Malinowski, Leszek; Mierzwińska, Gabriela; Nowak, Tomasz; Ogrodowicz, Ewa; Pędracka, Anna; Ptaszkiewicz, Marta; Rogóż-Duda, Agnieszka; Rydygier, Marzena; Sadowski, Bartłomiej; Skowrońska, Katarzyna; Stolarczyk, Liliana; Sowa, Urszula; Swakoń, Jan; Waligórski, Michael; Olko, Paweł
    Proton radiotherapy is an effective treatment modality for ocular cancer patients with choroidal melanoma. In 2011 a proton radiotherapy facility at the Institute of Nuclear Physics Polish Academy of Sciences was commissioned and went into clinical operation. By the end of the year 2015, a total of 128 ocular patients of the University Hospital in Kraków were irradiated at this facility, of whom 113 were treated under contract from the National Health Fund.
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    Influence of therapeutic proton beam on glioblastoma multiforme proliferation index – A preliminary study
    (Acta Physica Polonica A, 2019) Bogdali-Suślik, Anna M.; Rawojć, K.; Miszczyk, Justyna; Panek, Agnieszka; Woźniak, Monika; Szewczyk, Katarzyna; Książek, Teofila; Bik-Multanowski, Mirosław; Swakoń, Jan; Komenda, Wiktor; Mojżeszek, Natalia; Kajdrowicz, Tomasz; Kopeć, Renata; Olko, Paweł
    The goal of the presented study was to compare the proliferation of different U118 MG and U251 MG glioblastoma cell lines irradiated with proton beam or X-rays in dose range 0.5-10.0 Gy. Cytokinesis-block micronucleus (CBMN) assay was carried out to study changes in proliferation presented as nuclear division index (NDI). Preliminary results suggest that protons and X-rays influence GBM (glioblastoma multiforme) cellular proliferation differently. Therapeutically, a decrease in NDI values with the increase in both types of radiation dose was found only for U251 MG cell line, thus can be classified as more radiosensitive than U118 MG cell line. Also for U251 MG GBM cell line, a therapeutic proton beam was more effective in inhibition of proliferation than X-rays. Genetic differences between GBM are supposed to be involved in the increased radiosensitivity, which is planned to be studied further by genes expression analysis.